Cell-resolved transcript structures are essential for understanding how isoform usage, alternative polyadenylation, and allelic expression vary across cell types. However, existing single-cell long-read datasets remain fragmented across studies, platforms, species, and workflows, hindering comparison and reuse. Here, w...
Chromosome architecture is essential for faithful chromosome segregation and genome stability. However, the mechanisms underlying chromosome organization are not well-characterized. Here, we identify the ubiquitin ligase Ufd4p as a master regulator of chromosome organization. Ufd4p deficiency causes longer chromosome a...
Tai-Cong Tan, Ya-Li Mi, Peng Du et al.· Proceedings of the National...· 0 citations
Ovarian aging is marked by a progressive diminution of oocyte quality and quantity, and long-read sequencing improves isoform-level resolution of ovarian transcriptomic diversity and identifies candidate aging-associated transcript alterations that may be relevant to reproductive decline.
Haiyang Wu, Xiaoyu Yin, Min Zhang et al.· Journal of Ovarian Research· 0 citations
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