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Shen-Si Shen

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Review Open access Sep 2026

Decoding hidden inceptions: The evolution from indolent to aggressive cancers.

It is proposed that tumor indolence is an actively maintained condition of restrained malignant potential, sustained by a multilayer restraint architecture encompassing lineage and epigenetic barriers, epithelial cell competition, immune containment, stromal organization, and vascular and metabolic limitations.

Xin-Pu Tang, Tian-Jian Lu, Mengyao Wang et al. · 0 citations

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