Shen-Xing Li

scH16S‐Seq Maps Klebsiella pneumoniae‐Associated Myeloid States and Reveals a CD38–NAD Immunometabolic Axis That Impairs Lysosomal Acidification in Sepsis

ABSTRACT Sepsis arises from heterogeneous host‐cell states that influence bacterial clearance, yet single‐cell transcriptomic approaches do not directly connect microbial signals with host transcriptional programs. This study introduces single‐cell host–bacterial 16S co‐sequencing (scH16S‐seq), which couples host trans...