Metabolite-driven dysfunction of intratumoral tertiary lymphoid structures: single-cell and spatial omics perspectives on cancer immune escape
Intratumoral tertiary lymphoid structures (TLSs) are increasingly recognized as spatially organized immune niches associated with favorable prognosis and improved responses to immune checkpoint blockade. Yet TLS positivity is not synonymous with durable antitumor immunity. Many tumors contain lymphoid aggregates that a...