Author

Sheng-Hu Zhou

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Aug 2026

High-throughput screening coupled with laboratory adaptive evolution to enhance acid-tolerance and succinic acid production of Actinobacillus succinogenes.

The development of efficient bio-based succinic acid production technology holds significant importance for reducing carbon emissions and advancing the industrial production of biodegradable plastics. Actinobacillus succinogenes is a natural high-yield succinic acid producer. However, its fermentation is limited by low...

Sheng-Hu Zhou, Xiao-Juan Zhang, Yu Deng · Bioresource Technology · 0 citations

Review Jul 2026

Metabolic engineering strategies for astaxanthin biosynthesis in non-native microbial cell factories.

Astaxanthin, a C40 carotenoid with exceptional antioxidant, anti-inflammatory, and anticancer physiological activities, has experienced surging market demand across cosmeceutical, food, and pharmaceutical industries. Traditional astaxanthin production methods have critical limitations, including high costs, significant...

Asif Hussain, Habiba Bibi, Sheng-Hu Zhou et al. · Bioresource Technology · 0 citations

Open access Aug 2026

Deep learning-driven de novo design of ribosome binding sites in Paracoccus denitrificans

This work establishes the first deep learning-enabled RBS design platform for P. denitrificans, offering a robust tool for precise translational regulation and advancing synthetic biology applications in environmental biotechnology.

Zhiping Zheng, Shenghu Zhou, Yu Deng · Synthetic and Systems Biotec... · 0 citations