Author

Sheng-Hua Gao

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Review Open access Sep 2026

The substrate envelope strategy: Structural basis for resistance mitigation in antiviral drug design

This review highlights the “substrate envelope hypothesis”, a structure-based drug design (SBDD) paradigm that constrains the spatial boundaries and binding footprint of inhibitors within the conserved active site volume defined by natural viral substrates, and extends this strategy from traditional protease targets to...

Qiao-Ji Xu, Ji-Wei Zhang, Yan-Xu Hou et al. · Pharmaceutical Science Advan... · 0 citations

Review Sep 2026

Recent advances in the medicinal chemistry of HSV-1 inhibitors (2020-2025): Emerging targets, modalities, and translational challenges.

Herpes simplex virus type 1 (HSV-1) causes widespread human infection, for which curative therapies remain unavailable. First-line TK-dependent nucleoside analogues such as acyclovir fail to eradicate latent virus and show limited activity against drug-resistant variants, highlighting an urgent unmet medical need. This...

Qiao-Mei Zhou, Bao-Hu Li, Ye-Hong Dai et al. · European journal of medicina... · 0 citations

Sep 2026

Small-Molecule Antivirals against Severe Fever with Thrombocytopenia Syndrome Virus: From Viral Life Cycle Targets to Host-Directed Strategies

This perspective critically evaluates recent advances in the development of small-molecule anti-SFTSV agents, organized through a dual framework encompassing both viral life cycle targets and host-dependent pathways.

Zhou Tan, Ji-Wei Zhang, Chun-Hong Yin et al. · Journal of Medicinal Chemist... · 0 citations

Editorial Open access Jul 2026

Novel Mechanisms of SARS-CoV-2 Drug Resistance and Rational Design of Anti-Resistant Antivirals

Three effective countermeasures have been established: structure-based optimization of Mpro inhibitors, rational design of ExoN-evading nucleoside analogues, and synergistic combination therapies to combat emerging resistant SARS-CoV-2 variants.

Xianghan Bai, Bing Ye, Sheng-Hua Gao et al. · Molecules · 0 citations

Aug 2026

Discovery of piperazine-based multi-site occupying coronavirus Mpro inhibitors with potent and broad-spectrum antiviral activity.

The discovery and optimization of a novel series of piperazine-based Mpro inhibitors using a multi-site binding strategy guided by analysis of conserved residues within the coronavirus Mpro active sites are reported, highlighting the utility of structure-based design for the development of promising broad-spectrum anti...

Bing Ye, Myoung Kyu Lee, Letian Song et al. · European journal of medicina... · 0 citations