Open access
Aug 2026
The Role of IGF2BP3‐Mediated Immune Response Activation in Enhancing Immunotherapy of Koumine for Gastric Cancer
ABSTRACT Resistance to immune checkpoint blockade in gastric cancer often arises from defective antigen presentation due to MHC‐I downregulation, yet strategies to restore MHC‐I expression remain limited. Here, using the natural alkaloid koumine as a chemical probe, we identified IGF2BP3 as a druggable regulator of MHC...
Hong-Qiang Qiu, Hailing Lin, Lou Luqi et al.
· Cancer Science · 0 citations