Author

Sheng-Jun Wang

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Review Open access Sep 2026

Cellular crosstalk of fibroblast–myofibroblast transition in intestinal homeostasis and disease

Fibroblasts are central components of the intestinal microenvironment and can acquire a myofibroblast phenotype through fibroblast-to-myofibroblast transition (FMT), a process linked to increased tissue mechanosensitivity and active extracellular matrix (ECM) remodeling. In this way, FMT participates in normal intestin...

Hao-Dong Yuan, Lin Zhao, Pei-Qi Xu et al. · Biomarker Research · 0 citations

Open access Sep 2026

Histone H3K18 Lactylation Drives Immunosuppression by Upregulating CD38 in Myeloid-Derived Suppressor Cells in Lung Cancer.

Histone lactylation is an epigenetic modification that connects lactate metabolism with protein function. Our study identified lactate enhances the protein lactylation level not only in Myeloid-derived suppressor cells (MDSCs) of tumor-bearing mice, but also in the tumor tissues of lung cancer patients. This modificati...

Yao Dai, Hai-Yan Dai, Ya-Hui Wang et al. · Cancer immunology research · 0 citations