Review
Open access
Oct 2026
HIF-1α-mediated metabolic reprogramming in hypoxia-driven tumor metastasis
Tumor metastasis is a multistep process that requires profound metabolic plasticity to support cancer cell invasion, survival in circulation, colonization of distant organs, and metastatic outgrowth. Hypoxia is a hallmark of solid tumors and a major driver of metastatic progression. As a central transcriptional regulat...
Shu-Lun Shao, Meng-Xin Wang, Ren-Jian Xie et al.
· Frontiers in Cell and Develo... · 0 citations