AI Networking Cookbook: Practical recipes for AI-assisted network automation and development
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circRNA-based cancer vaccines and in vivo chimeric antigen receptor T (CAR-T) cell immunotherapies have been documented successively, but the issue of circRNA immunogenicity remains unresolved.
A cap-independent translation enhancer BBV is introduced and protein-encoding RNA oligonucleotides (PEOs) are developed, chemically synthesized RNAs bearing 5’-OH and 3’-P termini that drive rolling circle translation after endogenous circularization that built an IVT-free platform for rapid, safe, and highly druggable...
The BIRC5-NAMPT-TOP1 combination showed reproducible phenotypic activity in the tested genetic and pharmacological models and support the use of DeepMDS as a hypothesis-generation tool for higher-order target prioritization.
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