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Open access Sep 2026

An ancestral mitochondrial DNA insertion disrupts RNAi and enables persistence of a novel mycovirus in Cryptococcus neoformans

RNA interference (RNAi) is a widely conserved genome-defense mechanism that protects eukaryotes against viruses and transposable elements. We previously showed that RNAi loss can lead to hypermutation and antifungal drug resistance in the human fungal pathogen Cryptococcus neoformans, illuminating the potential clinica...

Jun Huang, Connor J. Larmore, Timothy C. Davenport et al. · 0 citations
Open access Aug 2026

Mycodnaviridae is a clade of giant viruses that persistently infect zoosporic fungi

Both “viral fossils” and active infection by giant viruses in fungi, particularly in the zoosporic phyla Blastocladiomycota and Chytridiomycota are reported, suggesting that viral activation may be constrained to certain life stages of the host.

J. Myers, F. Schulz, S. Rahimlou et al. · 2 citations

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