Sheng-Tao Yan

Sirtuin 3 attenuates sepsis-induced acute lung injury by suppressing NF-κB/NLRP3/GSDMD-mediated pyroptotic signaling.

BACKGROUND Sepsis is a major global health threat and frequently leads to acute lung injury (ALI). Pyroptosis has been increasingly implicated in the inflammatory progression of sepsis-induced ALI. Sirtuin 3 (Sirt3), a mitochondrial deacetylase, can regulate inflammatory injury and cellular stress responses. However, i...