Open access
Sep 2026
cGAS Downregulation Contributes to EGFR-TKI Resistance in NSCLC through the p-Nrf2–SIRT3–ROS/Ferroptosis Axis
Background: Although epidermal growth factor receptor (EGFR)-directed tyrosine kinase inhibition produces substantial initial benefit in EGFR-mutant non-small cell lung cancer, durable disease control is frequently compromised by the emergence of drug-resistant tumor cells. We therefore examined whether loss of cyclic...
Ya-Wan Zi, Hui-Lin Yu, Xiao-Hui Wang et al.
· Oncology Research · 0 citations