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Sheng-Hu Zhou

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Aug 2026

High-throughput screening coupled with laboratory adaptive evolution to enhance acid-tolerance and succinic acid production of Actinobacillus succinogenes.

By enabling efficient succinic acid production at low pH, the evolved A. succinogenes strains developed herein provide a feasible approach to lowering process costs and carbon emissions, accelerating the industrial adoption of bio-based succinic acid for biodegradable plastic production.

Sheng-Hu Zhou, Xiao-Juan Zhang, Yu Deng · 0 citations
Review Jul 2026

Metabolic engineering strategies for astaxanthin biosynthesis in non-native microbial cell factories.

Astaxanthin, a C40 carotenoid with exceptional antioxidant, anti-inflammatory, and anticancer physiological activities, has experienced surging market demand across cosmeceutical, food, and pharmaceutical industries. Traditional astaxanthin production methods have critical limitations, including high costs, significant...

Asif Hussain, Habiba Bibi, Sheng-Hu Zhou et al. · 0 citations
Open access Aug 2026

Deep learning-driven de novo design of ribosome binding sites in Paracoccus denitrificans

This work establishes the first deep learning-enabled RBS design platform for P. denitrificans, offering a robust tool for precise translational regulation and advancing synthetic biology applications in environmental biotechnology.

Zhiping Zheng, Shenghu Zhou, Yu Deng · 0 citations

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