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Shengquan Zhang

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Open access Aug 2026

A portable pathway specific transcription factor-promoter circuit enables heterologous production of fungal nonribosomal peptides

Most fungal nonribosomal peptide synthetase (NRPS) biosynthetic gene clusters remain transcriptionally silent, severely restricting the discovery of bioactive peptide metabolites. Standard constitutive promoters fail to support robust expression of large multidomain NRPS enzymes. Here, we identify a conserved subgroup...

Peng-Lin Wei, Yuanyuan Li, Zedong Ren et al. · 0 citations

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