Author

Shengsheng Ma

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Open access Sep 2026

Structural principles underlying the evolution of SWI/SNF chromatin remodelers

Adenosine 5′-triphosphate–dependent switch/sucrose nonfermentable (SWI/SNF)–family chromatin remodelers regulate genome accessibility by repositioning nucleosomes, yet how these complexes diversified across evolution while preserving a common remodeling mechanism has remained unresolved. Here, we determine cryo–electro...

Sheng-Sheng Ma, Ming-Dong Liu, Wan-Cheng Xu et al. · Science Advances · 0 citations

Open access Jul 2026

Shared CRISPR arrays underpin type I-A/I-B coexistence.

A shared-array logic in which Cas6a/Cas6b-compatible processing routes a single pre-crRNA to multiple type I effectors providing a potential mechanism for subtype co-existence, a plausible explanation for array-less (or "orphan") interference modules, and an evolutionary bet-hedging strategy that prevents Acrs from shu...

Kunming Liu, Chunjiang Ren, Xinyue Liu et al. · Protein & Cell · 0 citations