Shi-Bo Gao

Cu 2 ⁺-responsive hyaluronic acid nanoplatform for targeted curcumin delivery and suppression of osteolysis- and metastasis-related phenotypes in lung adenocarcinoma

Bone metastasis is a major cause of morbidity and mortality in lung adenocarcinoma and is closely associated with epithelial–mesenchymal transition (EMT) and tumor-derived osteolytic factors. Although curcumin exhibits promising anti-tumor and anti-metastatic activities, its poor solubility and low bioavailability li...