Author

Shi-Hua Wang

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Open access Jul 2026

HsfA-driven gene transcription regulates fungal morphogenesis and pathogenicity

It is demonstrated that A. flavus encodes two hsfA copies, whose knockdown or expression of a dominant-negative variant abrogates spore germination, a prerequisite for fungal development and colonization, and established HsfA as a pivotal regulator of A. flavus virulence and uncovered a novel HSF regulatory pathway.

X. Nie, Guo-Long Zhu, Bei Qin et al. · Virulence · 0 citations

Aug 2026

The Rab7 C-terminal intrinsically disordered region is a key determinant of development and pathogenicity in Aspergillus flavus.

The findings extend the mechanistic understanding of Rab7 beyond its catalytic pocket and establish the AflRab7 C-terminal IDR as a critical regulatory element that couples vacuolar dynamics to A. flavus development and aflatoxin biosynthesis, highlighting a tractable target for mitigating fungal toxigenic potential.

Yu Wang, Chunlan Xie, Xiaoliu Ming et al. · International Journal of Bio... · 0 citations