Shi-Jie Zhang

Atomistic Mechanisms of Allosteric Dysfunction in Wilson Disease: How Local ATP7B Mutations Propagate to Global Destabilization

Wilson disease (WD) is a severe metabolic disorder caused by mutations in the copper-transporting ATPase ATP7B. The MBD5–6 tandem module serves as a critical regulatory hub for the protein, harboring several pathogenic missense mutations, including T587M, A595T, and R616Q within the MBD6 domain. However, the atomisti...