Review
Open access
Aug 2026
Unraveling the Multifaceted Role of TRIM21 in Virus-Triggered Innate Immunity and Diseases
Tripartite motif-containing protein 21 (TRIM21/Ro52) is a pivotal E3 ubiquitin ligase and cytoplasmic fragment crystallizable receptor (FcR). It plays a crucial role in viral infections, autoimmune disorders, and cancers by regulating multiple cell signaling axes, including the NF-κB, RIG-I-like receptor (RLR), cGAS-ST...
Shi-Jin Lan, Ying Wang, Yu-Tong Fu et al.
· Biomolecules · 0 citations