Author

Shi-Jun Qiu

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Open access Sep 2026

Multimodal network alterations in diagnosis-age-defined early- and late-onset Alzheimer’s disease

Introduction Early-onset Alzheimer’s disease (EOAD) and late-onset Alzheimer’s disease (LOAD) may differ in large-scale network organization. We compared multimodal MRI markers of diagnosis-age-defined Alzheimer’s phenotypes. Methods Alzheimer’s Disease Neuroimaging Initiative participants were classified by age at fir...

Ze-Song Yuan, Jing Wang, Bao-Hua Cheng et al. · Frontiers in Neuroscience · 0 citations

Open access Aug 2026

Candidate Right Locus Coeruleus‐Centered Symptom Pathways in Young Major Depressive Disorder: A Multimodal Magnetic Resonance Imaging Study

Major depressive disorder (MDD) involves network‐level abnormalities that may reflect dysfunction in catecholaminergic nuclei, particularly the substantia nigra (SN) and locus coeruleus (LC), which regulate cortical gain and signal‐to‐noise ratio. However, whether MRI‐derived SN/LC phenotypes are linked to depressive s...

Ze-Song Yuan, Jing Wang, Danian Li et al. · Human Brain Mapping · 0 citations

Open access Aug 2026

Normative modelling of cortical networks identifies subtypes of type 2 diabetes associated with distinct clinical and transcriptomic profiles

Type 2 diabetes (T2D) is characterized by substantial clinical heterogeneity, yet its neurobiological substrates remain unclear. Here, we leverage normative modelling of cortical morphometric networks to quantify individual-level brain deviations using structural MRI data from 3,723 participants (1,941 T2D patients and...

Xiaoyue Wang, Zhizhong Sun, Jian-Cheng Cao et al. · bioRxiv · 0 citations