Objective The aim of this study is to explore the protective effect of esmolol against sepsis‐associated myocardial injury (SAMI) and its underlying molecular mechanisms. Methods SAMI‐related differentially expressed genes were identified from the Gene Expression Omnibus database (GSE267388). Potential targets of esmol...
Lei Zhao, Hua Dong, Shi-Min Dong· Cardiovascular Therapeutics· 0 citations
Sepsis-induced acute lung injury (ALI) remains a devastating complication of sepsis, marked by uncontrolled pulmonary inflammation, alveolar-capillary barrier disruption, and high mortality. Ferroptosis, an iron-dependent form of regulated cell death driven by lipid peroxidation, is implicated in sepsis-related org...
Jin Li, Ya-Zhou Li, Chun-Tao Song et al.· Frontiers in Immunology· 0 citations
Isoquercitrin mitigates sepsis-induced myocardial injury by targeting the EGFR/PI3K/AKT pathway, thereby inhibiting inflammation and apoptosis and represents a promising therapeutic candidate for sepsis-related cardiac damage.
He-Xin Zhai, Xing-Wei Yang, Yan Shao et al.· Biochemical and Biophysical...· 0 citations
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