Open access
Sep 2026
BaCas12a3 represents a new subtype of type V CRISPR effector with collateral activity toward tRNA
Abstract The CRISPR–Cas12 family encompasses diverse RNA-guided nucleases with both DNA- and RNA-targeting subtypes. They can trigger antiviral activities through either direct elimination of invading nucleic acids or activating broad collateral cleavage to induce abortive infection. Here, we report a novel type V CRIS...
Xin Li, Chen-Wei Wu, Jin-Shan Guo et al.
· Nucleic Acids Research · 0 citations