Open access
Oct 2026
AI-assisted discovery of an ABCA1/ABCG1 activator for restoring mitophagy and mitigating Alzheimer’s pathology
Defective mitophagy is a key pathological risk of Alzheimer’s disease (AD), yet available pharmacological agents capable of restoring mitophagy remain clinically limited, largely due to the lack of tools for drug screening and target identification. To address this, we introduce an integrated platform with three nove...
Zhi-Peng Ling, Jun-Ping Pan, Xiang-Lu Xiao et al.
· Molecular Neurodegeneration · 0 citations