Shi-Qian Shen

Discovery of a brain penetrant NLRP3 inflammasome inhibitor that reduces neuropathic pain in mice.

In our continuing campaign to discover novel inhibitors of the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) protein 3 (NLRP3), an emerging drug target that tightly regulates the innate immune responses, a 1H-1,2,3-triazole-4-carboxamide scaffold was designed and optimized. Iterative optimization...