Shi-Rong Wu

Integrated single-cell analysis characterizes malignant epithelial programs and context-dependent immune associations of MP7/SERINC2 in colorectal cancer

Introduction Colorectal cancer (CRC) comprises heterogeneous malignant epithelial states, but it remains unclear which transcriptional programs recur across patients and how these programs relate to the immune context. Methods We integrated five public single-cell RNA-sequencing datasets comprising 425,402 cells from 1...