Open access
Oct 2026
Synthesis and Preclinical Evaluation of 18F-CB86, a Novel Imidazole[1,2-a] Pyridine-Based TSPO Tracer
Background: The translocator protein (TSPO), an 18 kDa protein localized to the outer mitochondrial membrane, is a recognized biomarker of neuroinflammation. However, its clinical translation has been limited by factors such as poor specificity, low signal-to-noise ratio, and the influence of genetic polymorphisms (rs6...
Fan Zhang, Zhan-Hua Sun, Qiang Zheng et al.
· Pharmaceuticals · 0 citations