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Author

Shi-Yan Lai

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Review Sep 2026

Targeting Nicotinamide Metabolism to Reprogram the Tumor Microenvironment: Mechanisms and Novel Therapeutic Strategies.

The tumor microenvironment (TME) is characterized by heightened metabolic activity, dysfunctional vasculature, and chronic inflammation. Together, these features create an ecosystem that supports tumor progression. This review examines how nicotinamide (NAM) metabolism, mediated through its key enzymes Nicotinamide pho...

Wei-Dong Sun, Shuang-Zhou Bi, Xiao-Juan Zhu et al. · 0 citations
Review Aug 2026

NAMPT beyond NAD+ biosynthesis: roles in tumor microenvironment remodeling and cancer progression.

The multifaceted pro-tumorigenic mechanisms through which nicotinamide phosphoribosyltransferase (NAMPT) regulates key features of the TME, including macrophage polarization and immune responses, metabolic reprogramming and TME acidification, angiogenesis, and the maintenance of epithelial-mesenchymal transition and ca...

Wei-Dong Sun, Shuang-Zhou Bi, Xiao-Juan Zhu et al. · 0 citations

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