Shi-Yao Zhou

Integrated bioinformatics and experimental validation reveal lucanthone as a promising therapeutic agent targeting core genes in psoriasis.

Psoriasis is an immune-mediated chronic inflammatory skin disease driven by epidermal hyperproliferation and cutaneous immune dysregulation, yet lacks reliable diagnostic biomarkers. Here, we identified 14 core genes with excellent diagnostic value (AUC = 0.996), which were abnormally upregulated in psoriatic lesions,...