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Shiyong Liu

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Sep 2026

PEG-Lipid Interfacial Architecture Enables Zn2+-Dependent Redistribution of LNP-Mediated mRNA Expression Toward the Spleen.

PEG-lipid interfaces influence LNP nano-bio interactions, yet conventional PEG-lipid formulations differ simultaneously in several molecular features that complicate attribution of ion-dependent effects. Here, using structurally defined DMA-PEG16-OMe as a discrete PEG-lipid model and conventional DMA-PEG2k-OMe as a com...

Bing Shao, Ming-Long Chen, Cheng-Ying You et al. · 0 citations
Aug 2026

Macromolecular Design Principles for Polymer‐Lipid Hybrid Nanoparticles in RNA Delivery

This Perspective revisits cationic polymer-lipid nanoparticles not as historical precursors to ionizable lipid LNPs, but as a macromolecular materials space that can clarify and extend current RNA delivery design.

Bing Shao, Ming-Long Chen, Shi-Yong Liu · 0 citations

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