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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Shi Zhang

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Aug 2026

C646-loaded mesenchymal stromal cell extracellular vesicles alleviate lactate-driven immunoparalysis in sepsis-associated ARDS through the p300-H3K18la-PSMD14 axis.

Findings define a lactate-p300-H3K18la-PSMD14-AKT/mTOR pathway in immunoparalysis and support further preclinical evaluation of lactylation-targeted extracellular vesicle therapy.

Yuan-Yuan Zhang, Jia-Xu Guo, Jia-Ming Zhang et al. · 0 citations

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