Author

Shi-Zhe Diao

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Open access Sep 2026

Syndecan-4 drives immune escape in microsatellite-stable colorectal cancer by suppressing the formation of cytotoxic effector T cells via the PRKCA–TNFα–NF-κB axis

Approximately 85% of colorectal cancers (CRCs) are mismatch repair proficient/microsatellite stable (pMMR/MSS), a subtype that is resistant to immunotherapy because of its immunosuppressive tumor microenvironment (TME). However, the molecular determinants underlying immune evasion in MSS-type CRC remain incompletel...

Shun-Yi Wang, Yuehong Chen, Sheng-Zhi Ye et al. · Cell Death & Disease · 0 citations

#natural language process... Jun 2026

Zone of Proximal Policy Optimization: Teacher in Prompts, Not Gradients

Zone of Proximal Policy Optimization (ZPPO), inspired by Vygotsky's zone of proximal development, is introduced, which outperforms off/on-policy distillation and GRPO, with the largest gains at the smallest scale.

Byung-Kwan Lee, Ximing Lu, Shi-Zhe Diao et al. · arXiv.org · 2 citations