Lumbrokinase ameliorates chronic social defeat stress-induced behavioral impairments through modulation of miR-340-5p and SUMO2 signaling.
Chronic social defeat stress (CSDS) is a rodent model used to study mood-related disorders by mimicking social trauma and psychosocial stressors relevant to human society. We recently developed an intranasal lumbrokinase delivery that effectively reaches deeper brain structures, including the hippocampus, and mitigates...