Author

Shih-Chi Su

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Review Sep 2026

Flavones in osteosarcoma: Molecular mechanisms, antitumor activity, and translational challenges.

Osteosarcoma remains the most common primary malignant bone tumor, and survival has improved little over recent decades because of metastasis and therapeutic resistance. Flavones exhibit diverse anti-osteosarcoma activities by suppressing proliferation, inducing apoptosis, ferroptosis and autophagy, inhibiting metastas...

Ko-Hsiu Lu, Renn-Chia Lin, Meng-Ying Tsai et al. · Drug Discovery Today · 0 citations

Open access Sep 2026

Siglec-7 orchestrates mitochondrial dynamics and metabolic reprogramming to restrain human NK cell cytotoxic function

An association between Siglec-7 status, mitochondrial homeostasis, and metabolic fitness in NK cells, with Siglec-7NEG cells retaining a metabolically robust, cytotoxic phenotype is supported.

Shih-Chi Su, Nai-Ting Tsao, Tzu-Lin Wang et al. · Journal of Biological Chemis... · 0 citations

Review Open access Oct 2026

Targeting oral cancer with curcumin and its structural analogs: molecular mechanisms, pharmacokinetic optimization, and clinical translation.

Curcumin is a naturally occurring polyphenol extracted from turmeric (Curcuma longa) and is known for its diverse biological functions, such as antioxidant, anti-inflammatory, anti-migratory, and anticancer activities. However, its use in clinical cancer treatment remains constrained due to challenges like limited abso...

Shih-Chi Su, Chun-Wen Su, Chia-Yi Lee et al. · Archives of pharmacal resear... · 0 citations