Shih-Ying Wu

GABA shunt metabolism drives smoking-related peri-neuronal brain metastasis by hijacking synaptic signaling.

BACKGROUND Brain metastases are a major clinical challenge with poor prognosis, particularly in patients with a history of smoking. While neurons are abundant in the brain and capable of synaptic interaction with tumor cells, their role in brain metastasis remains poorly understood. Emerging evidence suggests that neur...