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Author

Shike Wang

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Open access Nov 2025

EMT activates ER-to-Golgi trafficking through upregulation of REEP2 to promote lung cancer progression

A CRISPR interference in vivo screen for membrane trafficking regulators identifies REEP2 as a critical mediator of the EMT-driven pro-metastatic membrane trafficking program, revealing a specific vulnerability in mesenchymal LUAD.

Kevin L. Fulp, Oluwafunminiyi Obaleye, Shike Wang et al. · 0 citations
Open access Jul 2026

EMT activates ER-to-Golgi trafficking through upregulation of REEP2 to promote lung cancer progression

Membrane trafficking governs the transport of molecules to both intracellular and extracellular locations, thereby maintaining cell homeostasis. During cancer progression, alterations in membrane trafficking are frequently observed. However, the mechanisms underlying the dysregulation of membrane trafficking in cancer...

Kevin L. Fulp, Oluwafunminiyi Obaleye, Shike Wang et al. · 0 citations

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