Monoclonal antibodies (mAbs) that target receptor-mediated oncogenic pathways have revolutionized oncology research. Better therapeutic indices are possible with these mAbs for targeted tumor treatment. This review covers receptor-targeted monoclonal antibodies targeting the EGFR, HER2, and VEGF pathways in solid t...
A. Chettupalli, Paramvir Singh Tomar, Shikha Yadav et al.· Current Drug Therapy· 0 citations
INTRODUCTION
Neurodegenerative disorders, including Alzheimer's, Parkinson's, Huntington's disease, and amyotrophic lateral sclerosis, remain difficult to treat because the Blood-brain Barrier (BBB) severely restricts therapeutic access to the central nervous system. This review evaluates BBB biology and the potential...
A. Singh, Shatrudhan Prajapati, Shikha Yadav et al.· Current Neurovascular Resear...· 0 citations
Therapeutic modulation of the SET-PP2A axis may provide a novel strategy for suppressing tumor progression and improving treatment outcomes, and further mechanistic studies and welldesigned clinical investigations are required to establish the therapeutic relevance of SET targeting and facilitate its integration into p...
Rohit Das, Shikha Yadav, Sudeshna Das et al.· Current Signal Transduction...· 0 citations
USP7 and USP22 play pivotal roles in GC progression by regulating multiple oncogenic signalling networks and further investigation into their molecular functions and therapeutic potential may provide new opportunities for improving the diagnosis, prognosis, and treatment of GC.
Rohit Das, Shikha Yadav, Sudeshna Das et al.· Current Pharmacogenomics and...· 0 citations
The synthesis of emerging evidence regarding the neuroprotective efficacy of phytotherapy is presented in this review, and the focus is on such traditional medicinal plants as Bacopa monnieri, Withania somnifera, and Centella asiatica.
Shatrudhan Prajapati, Shikha Yadav, A. Singh et al.· Current Pharmaceutical Biote...· 0 citations
Future studies must aim to design nanoparticles that maximize tumor uptake, incorporate predictive biomarkers, and optimize clinical utility and therapeutic efficacy to enhance translational success.
A. Singh, Shatrudhan Prajapati, Shikha Yadav et al.· Current Pharmacogenomics and...· 0 citations
Breast cancer is the most frequently diagnosed cancer and a
leading cause of cancer-related deaths worldwide. Despite significant advances in therapy, tumour heterogeneity, drug resistance, and treatment-associated toxicity remain major
challenges in clinical management. The shift from conventional systemic therapi...
The findings support the therapeutic potential of exosome-based platforms while also highlighting major challenges, including inconsistencies in isolation protocols, limited cargo- loading capacity, targeting specificity, and in vivo stability.
Shatrudhan Prajapati, Shikha Yadav· Current Neurovascular Resear...· 0 citations
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