Open access
Aug 2026
MORC1 coordinates TRIM28 interaction and nuclear condensate formation for transposon silencing
Summary MORC1-mediated transposon repression involves DNA methylation and H3K9me3 deposition, yet the underlying mechanism remains unclear. Here, we show that MORC1 assembles discrete nuclear bodies in gonocytes and, using a doxycycline-inducible NIH3T3 cell system, define two properties: MORC1 drives nuclear condensat...
Yosuke Isota, Pei-Lin Li, Kiichiro Sakata et al.
· iScience · 0 citations