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Author

Shiqi Jiang

2 papers indexed here

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Open access Sep 2026

Development and Validation of a UPLC–MS/MS Method for Simultaneous Quantification of Ensartinib and Its Major Metabolite M465 in Rat Plasma and Application to Pharmacokinetic Studies

A sensitive, reliable, and rapid UPLC–MS/MS method was developed and validated for the simultaneous determination of ensartinib and M465 in rat plasma and applied to a rat pharmacokinetic study and provides useful analytical support for further preclinical investigations of ensartinib and its major metabolite.

Shi-Qi Jiang, Yan Chen, Lu Cao et al. · 0 citations
Aug 2026

Simultaneous determination of bosutinib and its metabolite in rat plasma by UPLC-MS/MS: Development, validation and application to pharmacokinetic and metabolic stability studies.

Bosutinib is a second-generation tyrosine kinase inhibitor (TKI) primarily used for the treatment of chronic myeloid leukemia (CML). The aim of this study was to develop and validate a rapid and accurate ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) method for the simultaneous determinat...

Pei-Qi Wang, Yan Chen, Jun Wu et al. · 0 citations

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