Biochemical Investigation of PumG, a Key Pyridoxal 5'-Phosphate (PLP)-Dependent Aminotransferase Involved in Pseudouridimycin Biosynthesis.
Pyridoxal 5'-phosphate (PLP)-dependent aminotransferases play a central role in nucleoside antibiotic biosynthesis, where they catalyze the conversion of ribose-derived aldehyde intermediates into aminonucleosides by introducing critical amino functional groups. Despite their widespread occurrence in the biosynthetic p...