Author

Shivashankar Othy

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Open access Aug 2026

Lipid-driven membrane remodeling engages a lysosome-dependent adaptive repair program during retinal aging

Age-associated remodeling of membrane lipid composition has been implicated in cellular dysfunction, yet the mechanisms linking lipid changes to membrane integrity and disease remain poorly defined. In the retinal pigment epithelium (RPE), lipid dysregulation is strongly associated with aging and age-related macular de...

Emily Tom, Fang-Yuan Gao, Carolina N. Franco et al. · Molecular Neurodegeneration · 0 citations

Open access Sep 2026

Spatial Transcriptomics Reveals a T Cell‐Mediated Microglial Activation Axis of Immune Checkpoint Inhibition‐Related Adverse Events in the Brain

ABSTRACT Immune checkpoint inhibitors (ICIs) targeting CTLA‐4 and PD‐1 have transformed cancer therapy, yet their immune‐related adverse events (irAEs) in various tissues, including the brain, remain poorly defined. ICI perturbs hippocampal‐dependent memory function by derailing neuro‐immune homeostasis and compromisin...

Devyani Swami, Sanad M. El-Khatib, Suhas Sureshchandra et al. · Advancement of science · 0 citations

Open access Jul 2026

Optimizing T Cell Priming Using TLR4/9 Combination Adjuvant For Robust Cell-Mediated Immunity Against Influenza 2307646

This work investigates the potential of IVAX-1, a combination of TLR4 (MPLA) and TLR9 (CpG 1018) agonists formulated in a squalene oil-in-water emulsion, to mediate protection and generate CMI and demonstrates the potential of TLR agonist combinations to elicit durable T-cell immunity.

Dan Nguyen, D. Davies, J. Felgner et al. · Journal of Immunology · 0 citations