Aug 2026
Kinetically Programmed Thermoresponsive Polyethylene Glycol Shedding from Lipid Nanoparticles Improves mRNA Delivery.
Polyethylene glycol (PEG) can stabilize nanoparticles and facilitate transport across biological barriers, yet the same PEG layer suppresses cellular uptake─a trade-off known as the PEG dilemma. Current strategies seek to overcome this limitation by enabling PEG shedding in response to pathological biochemical cues, bu...
Si-Min Sun, Chen Yang, Yi-Xing Wen et al.
· Journal of the American Chem... · 0 citations