Author

Shiyu Zhu

2 papers indexed here

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Open access Jul 2026

Combined therapy with ALK inhibitors and a novel EGFR-targeting antibody‒drug conjugate as a strategy for ALK-rearranged non-small cell lung cancers.

Combinatorial strategies targeting distinct signaling pathways may overcome the limitations of single-agent targeted therapies and demonstrate the synergistic antitumor activity of ALK inhibitor plus LR004-VC-MMAE against ALK-rearranged, EGFR-high NSCLC, providing a mechanistic rationale for further clinical developmen...

Lan-wen Zhang, Xiaofan Wu, Jing-Fei Gao et al. · Oncogenesis · 0 citations

Jul 2026

hIMB1636-LDM, a novel anti-TROP2 ADC, exerts potent antitumor efficacy in pancreatic cancer via direct cytotoxicity and immune activation.

HIMB1636-LDM exerts potent antitumor activity through a dual mechanism combining targeted cytotoxicity and ICD induction, and was for the first time found to possess the ability to trigger immunogenic cell death (ICD).

Dan-dan Zhou, Dong-Cheng Jiang, Xiao-Rui Xu et al. · Biochemical Pharmacology · 0 citations