Identification and evaluation of repurposing Food and Drug Administration-approved drugs targeting the pE165R protein of African swine fever virus.
Objective African swine fever is a devastating swine disease lacking effective vaccines or antiviral drugs. The African swine fever virus (ASFV) pE165R deoxyuridine triphosphatase (dUTPase), critical for viral replication, is a promising antiviral target. Therefore, identifying inhibitors that target the pE165R protein...