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Shouzhi Chen

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Aug 2026

DiConSite: A Unified Topology-Adaptive Architecture for Protein Binding Site Prediction Across Ligand Modalities.

By combining protein language model embeddings with topology-adaptive geometric reasoning, DiConSite offers a reusable framework for residue-level protein interaction analysis and achieves consistently strong and often best-performing results, while improving robustness to structural uncertainty and cross-modal variation.

Shou-Zhi Chen, Zhenchao Tang, Linlin You et al. · 1 citation