Shraddha Upadhyay

Catalyst-Efficient Green Synthesis of 2,4-Diaminopyrimido[2,3-d]quinolines Using 1,3-Binucleophiles: A Sustainable Approach to Nitrogen-Fused Heterocycles

This study describes a quick and convenient procedure for the synthesis of 2-4 diamino pyrimido[2,3d]quinoline  starting from 2-aminoquinoline-3-carbonitriles. The method employs guanidine hydrochloride as an nucleophilic reagent, and sodium acetate as a mild base and iodine in DMF at 90 °C. In situ oxime formation and...