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Author

Shravani Balaji

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Sep 2026

Nsp1 from divergent coronaviruses has conserved endonuclease activity.

All alpha- and beta-coronaviruses encode nonstructural protein 1 (Nsp1), a major virulence factor that restricts host gene expression. Herein, using Nsp1 from divergent alpha- and beta-coronaviruses (SARS-CoV-2, MERS-CoV, and HCoV-229E), we reveal all tested coronavirus Nsp1 proteins have intrinsic endonuclease activit...

Michael B. Vetick, Shravani Balaji, Shannon Henry et al. · 0 citations

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