Abstract Viral 2A oligopeptides drive an unusual ribosome recoding event in which peptide-bond formation fails at a conserved PG↓P motif, producing two discrete proteins without canonical termination. Despite decades of study, the molecular basis of 2A-mediated peptide-bond skipping remains poorly understood. Here, we...
Xin-Cheng Wu, Saori Uematsu, Yan Wu et al.· Nucleic Acids Research· 0 citations
A profiling strategy to capture terminating ribosomes in mammalian cells is established and a substantial heterogeneity in ribosome pausing at individual stop codons is revealed, established as a distinct translational signature shaped by mRNA sequence contexts, ribosome heterogeneity, and cell type-specific translatio...
A profiling strategy to capture terminating ribosomes in mammalian cells is established and a substantial heterogeneity in ribosome pausing at individual stop codons is revealed, suggesting termination pausing as a distinct translational signature shaped by mRNA sequence contexts, ribosome heterogeneity, and cell type-...
