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Author

Shu-Bing Zhang

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Open access Aug 2026

Integrative multi-omics analysis reveals LLPS-associated CLEC2D⁺AR⁻ tumor-cell states linked to early adaptive progression toward castration resistance in prostate cancer

Findings provide a conceptual link between LLPS biology, AR-independent tumor-cell plasticity, and microenvironmental remodeling in CRPC, while nominating CLEC2D as a candidate marker and potential therapeutic target requiring further experimental validation.

Ze Cheng, Jinhua Yan, Shunkang Xue et al. · 0 citations
Open access Aug 2026

RFC5 and STAT3 form a transcriptional complex to drive NSCLC progression via c-Myc

It was revealed that RFC5 exerted a co-transcriptional activation function, which was negatively regulated by GATA3, to promote NSCLC progression by activating the STAT3-c-Myc signaling pathway.

Jinhua Yan, Tao Yi, W. Tian et al. · 0 citations

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