Author

Shu-Han Yang

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Review Open access Sep 2026

Epigenetic regulation of HIV-1 transcription: insights into latency mechanisms and therapeutic strategies

HIV-1 is one of the most serious pathogens currently threatening human health worldwide. Although antiretroviral therapy (ART) effectively suppresses HIV-1 replication, it fails to eliminate the latent reservoir of transcriptionally silent proviruses that persist in long-lived cells, making HIV-1 latency the major obst...

Shu-Han Yang, Jin-Song Yuan, Xiao-Dong Sun et al. · Frontiers in Cellular and In... · 0 citations

Open access Sep 2026

Deubiquitinase USP8 inhibits HIV-1 replication by suppressing Tat-mediated viral transactivation

ABSTRACT Ubiquitin-specific proteases (USPs) modulate diverse virus-host interaction events through deubiquitination; thus, investigating their functional roles and molecular targets facilitates the interpretation of viral pathogenic mechanisms and informs the design of anti-virus strategies. The deubiquitinase USP8 ha...

Jin-Song Yuan, Wei-Jing Yang, Ming-Xiu Xu et al. · Journal of Virology · 0 citations